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In the United States colorectal cancer (CRC) is the third more commonly diagnosed cancer in both sexes and it is also the third leading cause of cancer death among men and women [1]. In Europe CRC is the second leading cause of cancer death in both sexes [2]. These figures mean a heavy economic burden for any health system. The national cost of a year of CRC care in the United States has been estimated to be between $4.5 and $9.6 billion [3]. In Spain €180.6 million of annual loses in work productivity because of CRC have been reported [4].

In vivo Optical Diagnosis of Polyp Histology: Can We Omit Pathological Examination of Diminutive Polyps?