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Delivery of a functional DNA to mammalian cells is an attractive approach for genetic manip‐ ulation of the cells in biomedical research as well as in gene therapy for treating critical human diseases. Following delivery to the cytoplasm, a foreign gene enters the nucleus and is tran‐ scribed to the corresponding mRNA, which is subsequently transported to the cytoplasm for translation into a specific protein. However, a gene-silencing element, such as an antisense onligonucleotide or a small interfering RNA blocks the transcription of a target mRNA. Thus, nucleic acid delivery has been an essential tool either to turn on or off the expression of a particular gene in basic research laboratories.

pH-Sensitive Nanocrystals of Carbonate Apatite- a Powerful and Versatile Tool for Efficient Delivery of Genetic Materials to Mammalian Cells