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The role of infection in the etiology of leukemia was revealed for the first time more than ninety years ago through a series of cases reported by Gordon Ward in the year 1917. These cases included 1457 children with acute leukemia, but the results were inconclusive. Later, in another study by Poynton, Thursfield and Paterson, the authors reported that it was not possible to attribute the etiology of leukemia to a single infectious agent and emphasized the importance of host susceptibility in the acquirement of an infection and the development of acute leukemia.[1,2]

Infection During the First Year of Life and Acute Leukemia: Epidemiological Evidence