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Solid dispersion is one of the most efficient techniques to improve the dissolution rate of poorly water-soluble drugs, leading to an improvement in the relative bioavailability of their formulations. At present, the solvent method and the melting method are widely used in the preparation of solid dispersions. In general, subsequent grinding, sieving, mixing and granulation are necessary to produce the different desired formulations.

intech ebooks

Preparation of Carvedilol Spherical Crystals Having Solid Dispersion Structure by the Emulsion Solvent Diffusion Method and Evaluation of Its in vitro Characteristics