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Until 2005, T helper (CD4+) cells were proposed to be a binary system, consisting of TH1 and TH2 cells (Mosmann TR et al.,1986) , when a third T helper -cell subset, known as TH17 (interleukin-17 (IL-17) expressing cells), was identified (Harrington LE et al., 2005, Park H et al., 2005). This was followed up by the another independent discovery in three different laboratories of the differentiation factors cytokines such as interleukin (IL)-6 and transforming growth factor beta (TGF-┚), that simplified in vitro analysis of this T cell subset to a large extent (Veldhoen M et al., 2006, Bettelli E et al., 2006, Mangan et al., 2006). The discovery of these unique TH17 cells has opened up exciting new avenues for research into the etiology and therapeutics of a broad spectrum of human diseases and data on the biology of these cells have emerged at an astounding pace in just 5 years. The reason for these cells to receive considerable attention in these recent years is their emerging involvement as principal mediators of pathogenesis in several autoimmune and chronic inflammatory disorders. Many reviews of the field have already highlighted the important role of TH17 cells in the diverse group of human autoimmune and inflammatory diseases (Tesmer et al., 2008, Sallusto and Lanzavecchia 2009, Torrado and Cooper 2010, Kimura and Kishimoto 2011, Cosmi et al., 2011).

TH17 Cells in Cancer Related Inflammation