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It is generally accepted that infertility affects 15% of couples at reproductive ages. The causes of infertility are 38% female, 20% male, 27% mixed and 15% unknown (Ferlin et al., 2007). The male factor is the sole responsible party or a copartner in infertility in 50% of couples. About 7-8% of men have infertility problems or are the cause of miscarriages. Chromosomal causes rank high among the causes of infertility. 50% of first-trimester abortive eggs have aneuploidy (Hassold et al., 1980). In second and third-trimester miscarriages, the aneuploidy rate drops to 15% and 5%, respectively (Simpson, 2007). Among living newborns, 0.5% to 1% shows aneuploidy (Gardner and Sutherland, 2004). Among the infertile population, 15% of infertility is due to chromosomal or genetic reasons (Griffin and Finch, 2005).

Meiotic Chromosome Abnormalities and Spermatic FISH in Infertile Patients with Normal Karyotype