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The RCK (the tyrosine kinase gene v-ros cross-hybridizing kinase) family within the CMGC (CDK/MAPK/GSK3/CLK) group of the human kinome consists of ICK/MRK (Intestinal cell kinase/MAK-related kinase) (Abe, Yagi et al. 1995; Togawa, Yan et al. 2000), MAK (male germ cell-associated kinase) (Matsushime, Jinno et al. 1990), and MOK (MAPK/MAK/MRKoverlapping kinase) (Miyata, Akashi et al. 1999) (Fig. 1). In the N-terminal catalytic domain, they all share significant sequence homology with MAPK (mitogen-activated protein kinase) and contain a MAPK-like TXY motif in the activation T-loop. However, they display significant divergence in the composition of their C-terminal non-catalytic domains which may determine their functional specificity and confer distinct regulatory mechanisms.

Regulations and Functions of ICK/MAK/MOK - A Novel MAPK-Related Kinase Family Linked to Human Diseases