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In optical Doppler measurements, the path length of the light is unknown. This complicates the noninvasive diagnosis of tissue with light. For example, in laser Doppler blood flowmetry, the coherent light delivered into the tissue interacts with static as well as moving scatterers, e.g. red blood cells and it records values averaged over different and basically unknown path lengths. One of the important limitations of this technique is the dependence of the perfusion signal on the optical properties of the tissue, i.e. absorption coefficient, scattering coefficient and anisotropy factor. These dependences result from the varying optical path length of detected photons; the longer the optical path length the greater is the probability for Doppler scattering events to occur, thus yielding an overestimation of the blood perfusion, compared to the short path length situation [1].

intech ebooks

Path Length Resolved Dynamic Light Scattering Measurements with Suppressed Influence of Optical Properties Using Phase Modulated Low Coherence Interferometry