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The preimplantation period of mammalian development hosts very important cellular and molecular events. This period starts with the fertilization of oocyte by sperm, a process that reprograms the highly differentiated nuclei of these germ cells, and leads to the generation of a totipotent one-cell embryo. Then, the embryo performs cleavage divisions with short cell cycles to quickly increase its cell number. During this period, the genome of the preimplantation embryo manifests profound changes in nuclear and chromatin organization, histone modifications, and transcriptional activity. These genome alterations are also coupled to cell signaling pathways and their regulatory effects. The final product of the preimplantation development is a multi-cellular blastocyst containing three types of cells, epiblasts, hypoblasts, and trophoblast cells [1].

Immunocytochemistry in Early Mammalian Embryos