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Epithelia are specialized tissues that emerged early in evolution to subdivide the body into distinct parts and to form barriers by lining both the outside (skin) and the inside cavities and lumen of bodies. Functions of epithelial cells include secretion, absorption, protection, transcellular transport, sensation detection and selective permeability. To achieve these different tasks, several types of epithelial tissues emerged during evolution, all of them having one feature in common that is indispensable for their function: the cells are attached to each other in order to form a layer that works as a barrier. Epithelial cells thus show a ordered morphology, they are polarized. Disruption of polarity is an important feature of epithelial cancers that accounts for more than 90% of fatal malignancies in adults, rendering the understanding of the fundamental processes needed for polarity an ongoing subject of high interest.

Drosophila: A Model System That Allows in vivo Manipulation and Study of Epithelial Cell Polarity