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Since its discovery in 1985, fullerene has been extensively investigated as a unique, “dissolvable,” and “modifiable” nanocarbon material. The most representative fullerene, C60, is a perfectly spherical molecule with a diameter of ca. 1 nm (0.7 nm when the distance between the furthest C–C bond is considered, and 1 nm when the -orbitals are included). It has many interesting electronic and biological properties owing to its spherical conjugation. While fullerenes satisfactorily dissolve in aromatic solvents such as toluene and o-dichlorobenzene as well as in carbon disulfide, they dissolve poorly in most common solvents such as hexane, chloroform, diethyl ether, ethyl acetate, tetrahydrofuran (THF), acetone, acetonitrile, ethanol, and even in benzene. This limitation has been one of the important issues hindering their practical application, especially in the field of life sciences.

Water-Soluble Single-Nano Carbon Particles: Fullerenol and Its Derivatives