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Within the last 20 years nanotechnology has broadened our perspective of different well established disciplines. One of these is virology, which through the development of techniques for the manipulation of single nanoobjects has evolved and acquired a new direction giving birth to the new emerging field of physical virology. An excellent review on this has been recently published (Roos, et al., 2010). Viruses, originally conceived only as harmful parasites, causatives of disease are now being investigated from a single particle point of view. The intrinsic mechanical properties of individual viruses have started to be unveiled by means of ultrasensitive surface probe techniques such as Atomic force microscopy (AFM) (Roos & Wuite, 2009). The profiler device is an ultrasharp tip which is also being used for probing viruses with piconewton (10-12 N) loading forces.

Force Microscopy – A Tool to Elucidate the Relationship Between Nanomechanics and Function in Viruses