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Pharmacokinetic (PK) studies are a crucial part of drug discovery. These studies require analysis of high numbers of plasma or serum samples from animals and humans to measure concentrations of peptide-/protein-drugs. The demands to assays are that they have a high capacity, only need low sample volumes, have a broad working range to avoid testing too many dilutions of samples, and have a good sensitivity. They have to be fast to develop and preferentially be more or less ready “on the shelf”. When new drug candidates like peptides, proteins or peptide-/protein-analogues are developed it is important that assays are available to all relevant peptide-/protein-drugs in due time.

Wash-LOCI - A Semi-Heterogeneous Version of the LOCI Technology Allowing Removal of Unbound Material After Each Assay Step