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Cellulose membranes have been used in the medical field as wound dressing and artificial skin material for the treatment of skin wounds such as burns, ulcers, and grafts and as an adjuvant in dermal abrasions (Cheng et al., 2009; Fontana et al., 1990). Using liposomes as drug-delivery strategies in connection with a cellulose-based wound dressing might have important impact on increasing the efficacy of wound healing. The concentration of liposomes used in this therapy is crucial. The amount of liposomes might permit increasing the efficacy of their diffusion through the cellulose membrane. In the present study we propose a laser interferometric method as a novel technique to investigate liposome diffusion through membranes and cellulose-based wound dressing to optimize drug delivery.