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Enzymes are catalytic protein molecules performing specific functions in their native form. Native structure is one of basic conditions for normal function of proteins including enzymes. Catalytic activity of enzyme may be decreased by both non-covalent modulation by true inhibitors and covalent modifications by metabolites in the body or natural products. One example of such modulation is non-enzymatic glycation of proteins by sugars.

Non-Enzymatic Glycation of Aminotransferases and the Possibilities of Its Modulation