English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Prostate cancer is the most common malignancy and second leading cause of cancer related death in males in developed countries (Jemal et al. 2011). Patients with localized and metastatic prostate cancer are treated with anti-androgens. Although prostate cancer cell proliferation is initially blocked or slowed down with anti-androgen therapy, eventually castration-resistant disease develops (Sharifi, Gulley & Dahut 2010). Therapeutic options for castration-resistant prostate cancer are limited and treatment responses to currently existing therapies are often unsatisfactory (Bracarda et al. 2011). For example, the cytotoxic therapy often causes severe toxicity and eventually leads also to the development of chemoresistance (Tannock et al. 2004, Berthold et al. 2008, Bracarda et al. 2011). Thus, there is an urgent need for novel agents to block the proliferation and to inhibit the progression of the primary prostate cancer cells to the advanced stage as well as to target advanced and metastatic prostate cancer. Therefore, understanding of disease progression and drug resistance mechanisms may provide valuable insights into the development of novel treatment options to improve the survival of prostate cancer patients.

Monensin Induced Oxidative Stress Reduces Prostate Cancer Cell Migration and Cancer Stem Cell Population