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Simultaneously with the rapid development of a wide range of antibacterial agents since the 1940s, bacteria have proved extremely adept at developing resistance to each new employed agent. The rapidly increasing incidence of bacterial resistance to antimicrobial agents has become a serious problem worldwide. Resistance mechanisms have been identified and described for all known antibiotics currently available for clinical use (Fluit et al., 2000).

From Synthesis to Antibacterial Activity of Some New Palladium(II) and Platinum(IV) Complexes