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Diabetic nephropathy is a life-threatening complication of diabetes mellitus and the leading cause of end-stage renal disease (ESRD) in developed countries. Diabetes is responsible for over 40% of all new cases with ESRD in the United States and Japan, eventually undergoing renal dialysis or transplantation. Diabetic nephropathy is characterized by glomerular hyperfiltration and thickening of glomerular basement membranes, followed by expansion of extracellular matrix in mesangial area. There are many factors and pathways that are involved in the pathogenesis of diabetic nephropathy. In this chapter, we will focus on advanced glycation end-products (AGE) and the receptor for AGE (RAGE) in the development and prevention of diabetic nephropathy.

Significance of Advanced Glycation End-Products (AGE) and the Receptor for AGE (RAGE) in Diabetic Nephropathy