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Twenty years ago, Farmer, Packard, and Perelson presented an elegant dynamical model [1] to study Idiotype Network theory [2-19], in which they showed that every molecular and cellular binding site (cell receptor) can be modeled by binary bit-strings of length l. In such a model, an antibody molecule can always recognize an antigen when there is complementarity between their bit-strings. The coincidence of antigens and lymphocyte receptors (lock-and-key model) is determined by considering the number of complementary bits [8,20]. For instance, if a B lymphocyte is represented by a binary string 00010101 (l = 8) and an antigen is represented by the 11101010 binary string, the immune response is activated (Fig. 1). The match between bit-strings does not need to be perfect, however; some bit positions are allowed in which two strings differ. These differences between strings (mismatches) reflect the degree of affinity between the entities of the immune system in mammals and determine the quality of the response.

An Ag-Dependent Approach Based on Adaptive Mechanisms for Investigating the Regulation of the Memory B Cell Reservoir