English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Acute myeloid leukemia (AML) is a neoplastic disorder characterized by the clonal expansion of non-lymphoid hematopoietic progenitor cells with failure of normal hematopoiesis. Several biological and clinical parameters have been identified at diagnosis to classify different AML subtypes with different prognosis. In this view, genetic abnormalities confer the most important prognostic information. Therapeutic interventions based on conventional or high-dose chemotherapy have significantly improved the complete remission (CR) rates of acute leukemia. However, a significant portion of responding patients still harbors a minimal residual disease (MRD), which is often resistant to further pharmacological treatments and ultimately leads to disease relapse and progression. Although allogeneic stem cell transplantation may significantly improve the clinical results of AML patients who achieved complete remission, such approach has several and important limitations and is not applicable to all the patients. For these reasons, novel therapeutic approaches to improve the clinical outcome of AML patients are under investigation, and treatments with high compliance such as adoptive and active immunotherapy are desirable. Aim of the present work will be to focus the most relevant insights in the field. In particular, we will report about the use of natural killer (NK) cells as a means of adoptive immunotherapy against neoplastic cells, including AML. Moreover, we will discuss the role of vaccines against leukemia with particular emphasis on the immunogenicity of novel and promising leukemia-associated antigens.

intech ebooks

Targeting the Minimal Residual Disease in Acute Myeloid Leukemia: The Role of Adoptive Immunotherapy with Natural Killer Cells and Antigen-Specific Vaccination