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Immunohistochemistry is an important technique used to visualize specific changes in tissues as part of both normal development and pathological conditions. Immunohistochemistry (IHC) combines antibody specificity with high resolution imaging techniques which, together, can provide reliable visual evidence of presumed physiological processes. The technique is amenable to rigorous experimental design. In controlled settings, with the appropriate constraints, and image acquisition settings, data obtained becomes reliable, quantifiable and reproducible. Through the numerous past and current explorations of IHC, novel, antibody-based, ‘point of care’ diagnostics as well as antibodybased therapeutics will and are becoming a valuable tool for clinicians and researchers. A field that really craves such new diagnostic and therapeutic technologies is that of traumatic brain injury.

Immunohistochemical Correlation of Novel Biomarkers with Neurodegeneration in Rat Models of Brain Injury