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Due to an error prone reverse transcriptase, HIV-1 has diversified into multiple variants. Currently, there are four phylogenetic groups named M, N, O and P (Gurtler et al., 1994; Plantier et al., 2009b; Simon et al., 1998). HIV-1 group M, which is responsible for most of the infections in the world, has diversified into nine subtypes named A, B, C, D, F, G, H, J and K, seven sub-subtypes (A1-A5 and F1-F2), multiple circulating recombinant forms (CRFs) and countless unique recombinant forms (UFRs) (Gao et al., 2001; Meloni et al., 2004; Triques et al., 1999; Vidal et al., 2009; Vidal et al., 2006). At present, 49 CRFs were recognized of which 37 are first generation recombinants and 12 are second generation recombinants (Los Alamos Sequence Database, 2011).

HIV-1 Diversity and Its Implications in Diagnosis, Transmission, Disease Progression, and Antiretroviral Therapy