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Recent studies have identified an increased incidence of the normally rare imprinting disorders, Beckwith-Wiedemann syndrome (BWS; NIM130650) and Angelman syndrome (AS; NIM105830), in ART babyes (DeBaun et al., 2003; Gosden et al., 2003; Maher, 2005). The identification of epigenetic changes at imprinted loci in ART babyes has led to the suggestion that the technique itself may predispose embryos to acquire imprinting errors. Both in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with the increased risk of imprinting disorders and it is not clear at what point these imprinting errors arise (Bowdin et al., 2007; Doornbos et al., 2007).

Aberrant DNA Methylation of Imprinted Loci in Male and Female Germ Cells of Infertile Couples