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A broadly effective malaria vaccine is a missing component of the practical tools needed to control and eventually eliminate malaria. For more than 50 years malaria researchers have been searching for a strategy that provides long lasting protection against a broad range of parasite strains. Many different approaches have been tested including whole parasite and subunit vaccines composed of one or more parasite surface proteins that are naturally targeted by the host immune response.

Using Population Genetics to Guide Malaria Vaccine Design