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Gastrointestinal stromal tumours (GISTs) represent the most common non-epithelial mesenchymal tumours of the gastrointestinal tract. The role of the pathologist in the differential diagnosis of GISTs, as well as the correct understanding of these neoplasia by detailed clinicopathologic, biological and genetic studies, are becoming increasingly important in optimizing the management of these tumours and to develop new therapies for the treatment of advanced diseases.

GISTs: From the History to the Tailored Therapy