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Age-dependent hearing loss involves pathological changes affecting the peripheral as well as the central auditory system. The Mongolian Gerbil is a rodent with an average life span of 3-4 years, which shows, in contrast to mice and rats, sensitive hearing in the frequency range that is important for human communication. Consequently, gerbils have been used to study structural and functional aspects of age-dependent hearing loss at the level of the cochlea and auditory brain stem nuclei. In addition, age-dependent changes in behavioural performance have been characterised for different auditory tasks. We have also analysed the effect of certain drugs on impaired temporal processing in old gerbils. The data from gerbils contribute to a framework that helps to better understand the mechanisms contributing to age-dependent hearing loss and may lead to new pharmacotherapeutic strategies for the treatment of age-dependent central hearing loss.

The Mongolian Gerbil as a Model for the Analysis of Peripheral and Central Age-Dependent Hearing Loss