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Many squamous cell carcinoma (SCC) of the head and neck presents with locally advanced disiease. In such cases, a combination chemotherapy of docetaxel, cisplatin, and 5FU, followed by radiation improved their survival (Posner et al. 2007; Vermorken et al. 2007). That is, addition of docetaxel to the combination of cisplatin and fluorouracil improves survival in head and neck squamous cell carcinoma. In a recent work to elucidate the possible mechanism, we investigated the effect of docetaxel on cell movement using head and neck cancer cell lines Hep2 and Ca9-22. Docetaxel treatment suppressed migration and invasiveness of head and neck cancer cells in vitro. We investigated the downstream effectors that control invasiveness after docetaxel administration in the present work.

Microtubule and Cdc42 are the Main Targets of Docetaxel’s Suppression of Invasiveness of Head and Neck Cancer Cells