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The pancreas is a dual-function organ featuring both endocrine and exocrine tissue. Endocrine functionality is provided by approximately one million cell clusters called the islets of Langerhans. Islets consist of four main cell types, 1) ┙ cells: secrete glucagon (increases glucose in blood); ┚ cells: secrete insulin (decreases glucose in blood); ├ cells: secrete somatostatin (regulates ┙ and ┚ cells) and PP cells: secrete pancreatic polypeptide. Thus, the islet plays a diverse role in glucose metabolism and blood glucose homeostasis.

Bioartificial Pancreas: Evaluation of Crucial Barriers to Clinical Application