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Multidrug resistance (MDR), the intrinsic or acquired ability to tolerate toxic concentrations of structurally and functionally diverse chemicals, is a widespread phenomenon that can be found in all living organisms, from bacteria to man (Hayes and Wolf 1997). Its negative consequences include the failure of many therapeutic, antimicrobial and crop protection actions. At the same time, the ability to tolerate multiple stresses is a highly desirable phenotype in organisms used as cell factories that have to cope with fermentation-related stresses (Teixeira et al. 2011b). It is, thus, crucial to understand the molecular basis underlying this phenomenon to be able to circumvent it or to explore it to design more robust industrial strains.

intech ebooks

Complex Regulatory Interplay Between Multidrug Resistance and Oxidative Stress Response in Yeast: The FLR1 Regulatory Network as a Systems Biology Case-Study