English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Gastrointestinal stromal tumor (GIST) express the cell surface transmembrane receptor KIT that has tyrosine kinase activity and is the protein product of the KIT proto-oncogene c-kit. Activation or gain-infunction mutation in the c-kit gene has been identified in the majority of GIST cases. The mutation results in the constitutive activation of KIT signaling, which leads to uncontrolled cell proliferation and resistance to apoptosis. Somatic mutation in the c-kit gene of GIST has been reported to be associated with aggressive progression and poor prognosis. The diameter of the tumor and the mitotic index have been reported as useful indices of the biological malignancy of GISTs. However, a few cases in the benign group had high cellularity, ulcer formation or metastasis/recurrence. Therefore, other indices of the biological malignancy of GISTs are thought to be needed. Recently, the Ki-67 labeling index, p53 immunoreaction, and bcl-2 overexpression have each been reported to be useful in predicting the potential malignancy in GISTs. In this chapter, the reliabilities of the Ki-67 labeling index, the expression of c-kit, p53, and bcl-2, and the apoptotic count for predicting potential malignancy were assessed.

intech ebooks

The Significance of the Ki-67 Labeling Index, the Expression of c-kit, p53, and bcl-2, and the Apoptotic Count on the Prognosis of Gastrointestinal Stromal Tumor