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The EBV-encoded RNAs (EBERs) are the most abundant EBV transcripts (about 107 copies per cell) during latent infection by EBV in a variety of cells. Owing to its expression abundance and universal existence in all of the 3 forms of latent infection, EBERs have been under intensive studies since they were discovered by Lernar (Lerner et al., 1981) for the first time. Looking back over the past 30 years, great efforts have been made to unveil the accurate role of EBERs in the latency and transformation process, the definite secondary structure and the signaling pathways they participate in. Despite significant achievements were achieved in these fields, most pioneer work was conducted in lymphoma cells. Bearing this in mind, we explore the similarities between lymphoma and carcinoma to fill the gaps in our knowledge of EBERs’ roles in nasopharyngeal carcinoma (NPC). However, it remains to be clarified whether the same scenario accurately applies to the pathological significance of EBERs in NPC.

Pathologic Significance of EBV Encoded RNA in NPC