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Till the end of 1980s transmission of the message carried by the hormone was thought to be mediated by a single estrogen receptor only. In the mid 1990s studies were published which described the discovery of a new estrogen receptor in both animals and humans [4-7]. The new estrogen receptor, ER-proved to be highly homologous to the classical estrogen receptor, ER- Functional differences at the molecular level between ER- and ER- are of principal importance for the body. Just as importantly, in the case of estrogen receptors the same ligand may play role of either an agonist or antagonist, depending on whether it binds to ER- or ER-. Therefore, following binding of the ligand ER- and ER- may induce distinct biological effects, linked to conformational changes of the receptor [8].

Expression of Estrogen Receptors in Placentas Originating from Premature Deliveries Induced by Arterial Hypertension