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Hypothermia (HT) is one of the most effective neuroprotective therapies for brain injury caused by cardiac arrest in humans (Benard et al., 2002), although there is as yet no evidence of such an effect of HT on cerebrovascular diseases from a large-scale clinical trial. We recently reported the experimental studies on the importance of timing of HT using global cerebral ischemia in mice (Doshi et al., 2009, 2011). we summarized our findings in this chapter because our results may be relevant to clinical studies.

Timing of Hypothermia (During or After Global Cerebral Ischemia) Differentially Affects Acute Brain Edema and Delayed Neuronal Death