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The majority of patients who require intervention for coronary artery disease are adequately treated by percutaneous coronary interventions (PCI) or coronary artery bypass grafting (CABG). However, a major reason for failure of these treatments is their dependency on luminal size and coronary outflow. Methods stimulating myocardial angiogenesis and new vessel formation that are not dependent on vessel caliber therefore provide an important alternative means of treatment. Topical negative pressure (TNP) has been used in the treatment of chronic and problematic wounds since the beginning of the 1990 s, and has been shown to increase blood flow and stimulate angiogenesis in the underlying tissue. Because of TNP s stimulating effect on blood flow and angiogenesis TNP has been tried to be applied directly onto the myocardium, referred to as myocardial topical negative pressure (MTNP) to increase myocardial blood flow and reduce myocardial ischemia, and reduce myocardial infarction (Lindstedt et al. 2008a, Lindstedt et al. 2008b, Lindstedt et al. 2007c, Lindstedt et al. 2007a, Lindstedt et al. 2007b, Lindstedt et al. 2008c, Lindstedt et al. 2008d).

Topical Negative Pressure, Applied onto the Myocardium, a Potential Alternative Treatment for Patients with Coronary Artery Disease in the Future