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Objective To investigate various kinds of causes and consequences for misdiagnosis and mistreatment of osteosarcoma (OS). Methods The data from 47 patients with osteosarcoma undergoing misdiagnosis and mistreatment were collected and their clinical causes and consequences were analyzed retrospectively. Results The causes contributing to the misdiagnosis among 47 patients included that patients delayed consulting their doctor (18 cases,38. 3%),patients underwent medical misdiagnosis and both of components occurred simultaneously(12 cases,25. 53%). The average duration of misdiagnosis was 72. 15 d, 57. 34 d and 100.68 d, respectively. Fourteen cases(29. 79%) accepted traditional Chinese medicine therapy, 11 (23. 40%) cases were treated by incorrect operation. Perhaps there were 28 patients (59. 57%)loosed limb-salvage procedure opportunity, 8 patients (17. 02%) had recurrence after limb-salvage operation, 20 patients (42. 55%) underwent metastasis induced by misdiagnosis and mistreatment. Conclusions The main cause of misdiagnosis and mistreatment of OS is medical misdiagnosis, patients and their parents have deficient professional knowledge of OS. CT and MRI examinations are the most effective procedures to prevent the misdiagnosis of early OS. The probability of all kinds of diagnoses should be estimated sufficienty, the therapeutic protocol should be made consummately and any other treatment procedures should not be taken blindly for the atypical cases before operation or biopsy.

Misdiagnosis and Mistreatment for Osteosarcoma: Analysis of Cause and Its Strategy