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The largest and most distinctive class of mycobacteria-specific genes encode a group of 167 proteins of repetitive sequence belonging to the pe and ppe families. The uniqueness of the ppe genes is illustrated by the fact that these genes are restricted to mycobacteria (Cole et al., 1998; Voskuil et al., 2004 (b)). The Rv2108 gene belongs to this family and furthermore is highly specific for the Mycobacterium tuberculosis (Mtb) complex group of mycobacterium (containing notably Mycobacterium africanum, Mycobacterium canettii, Mycobacterium microti, Mycobacterium pinnipedi, Mycobacterium bovis and M. bovis BCG strain). This gene was described by Chevrier et al., (2000) and used as a molecular probe to develop a rapid test for the detection and identification of this group of mycobacteria. Rv2108 is a gene coding for the protein P27-PPE36, member of the PPE protein family of Mycobacterium tuberculosis, a group of protein thought to be of immunological significance despite the fact that the exact role of the PPE proteins stills unknown.

P27-PPE36 (Rv2108) Mycobacterium tuberculosis Antigen – Member of PPE Protein Family with Surface Localization and Immunological Activities