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The lymphomas are a heterogeneous group of malignant diseases, which vary with respect to their molecular features, genetics, clinical presentations, treatment approaches and outcomes. They are divided into two broad groups on the basis of pathology: Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). They comprise approximately 5% 6% of all malignancies and are the fifth most frequently occurring type of cancer in the Western world (Jemal A et al., 2009). HD and many histological sub-types of NHL are potentially curable with appropriate chemotherapy and/or involved-field radiotherapy, and patients with disease relapse may be cured by second-line salvage treatments (Hampson FA and AS Shaw, 2008). Accurate staging and response assessment are essential to guide treatment decisions. Molecular imaging has become an essential tool in the early diagnosis (guiding biopsy), initial staging and risk stratification, monitoring response to therapy, and detection tumor recurrence of lymphomas. Research in molecular imaging is also contributing to our understanding of the disease pathogenesis of lymphomas and helping to direct more effective care of patients with the diseases.

Diagnostic and Treatment Response Imaging in Lymphomas