English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

The study of in vivo bioscience and medical treatment from molecular point of view requires the precise evaluation of molecule behavior in living systems, especially involving the human body. Positron emission tomography (PET) is a non–invasive imaging technology with a good resolution, high sensitivity, and accurate quantification, which makes it possible to timely and spatially analyze the dynamic behavior of molecules in in vivo systems using a specific molecular probe labeled with positron–emitting radionuclides such as 11C, 13N, 18F, and 76Br (Phelps, 2004). PET has been extensively used for the diagnosis of diseases such as cancers, cerebral dysfunction, and etc., and recently, in medical checkups as an early detection approach. In the current paradigm shift to drug discovery, PET molecular imaging will provide an important new scientific platform to execute human microdosing trials during the early stage of drug development, especially from the viewpoint of promoting evidence–based medicine (Lappin & Garner, 2003; Bergström et al., 2003). A core concept and the driving force of molecular imaging would truly be “Seeing is Believing”. It is of significant value to unveil the vital functions and phenomena of living systems by molecular imaging the in vivo behavior of a ligand and the localization of a biologically significant target molecule. The potential of PET molecular imaging in an interdisciplinary scientific area strongly depends on the availability of suitable radioactive molecular probes with specific biological functions. The development of biologically significant novel PET probes will be accomplished by the combination of an efficient synthetic strategy for designed molecules and new advances in the field of labeling chemistry (Schubiger et al., 2007).

intech ebooks

Pd0–Mediated Rapid C–[11C]Methylation and C–[18F]Fluoromethylation: Revolutionary Advanced Methods for General Incorporation of Short–Lived Positron–Emitting 11C and 18F Radionuclides in an Organic Framework