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Vascular endothelial growth factor (VEGF) is a key mediator involved in the control of angiogenesis and vascular permeability and has been shown to be induced by hypoxia in cultured human retinal pigment epithelium (RPE) [3]. VEGF-A is the most potent promoter of angiogenesis and vascular permeability within the VEGF family and its role in the pathogenesis of neovascular AMD is well recognized [4, 5]. The advent of intravitreous VEGF inhibitors has revolutionized the management of neovascular AMD. Yet, frequently, indefinite injections of VEGF blocking agents introduce a significant treatment burden for patients with neovascular AMD, and may potentially put patients in the risk of developing ocular and systemic adverse effects from injections. Many studies on modified treatment regimens have been performed in an attempt to mitigate this burden without compromise to visual acuity outcomes. Meanwhile, various randomized clinical trials on combination therapies and efforts to develop new pharmacologic agents are ongoing.

Promising Treatment Strategies for Neovascular AMD: Anti-VEGF Therapy