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The idea that G-protein-coupled receptors (GPCRs) may generate or modify various functions as dimmers or higher-order oligomers is now generally accepted. Significant numbers of GPCRs exit as heteromeric assemblies (refered to as hetero-oligomerization), generating novel functions for ligand binding and second messengers, and in turn creating unique receptor trafficking systems for pharmacological profiles (Angers et al., 2002, Bulenger et al., 2005). This is also true of the purinergic receptor family. Over recent years, we have explored many biochemical and pharmacological aspects of this particular family via hetero-oligomerization between metabotropic (i.e. G protein-coupled) purinergic receptors (particularly between P1 and P2), in which the agonists are metabolites playing important role in the purinergic signaling cascade.

intech ebooks

Application of Quantitative Immunogold Electron Microscopy to Determine the Distribution and Relative Expression of Homo- and Heteromeric Purinergic Adenosine A1 and P2Y Receptors