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Several microorganisms take advantages of the most common single gene disorder afflicting Caucasians and colonize the airways of cystic fibrosis (CF) patients. Although CF is a multisystem disorder, the associated mortality is mostly due to respiratory problems subsequent to chronic bacterial infections. CF is the result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) which is a cAMP-regulated chloride channel and a regulator of the activity of other channels. Consequently, there is a significant dehydration of the airway mucus when CFTR is dysfunctional. However, the exact reason why CF predisposes the lungs to microbial infections is not completely understood. It is thought that the obstruction of the airways by mucus and the proinflammatory status associated with this disease may be part of the explanation (Lyczak et al., 2002; Riordan, 2008).

Outcome and Prevention of Pseudomonas aeruginosa-Staphylococcus aureus Interactions During Pulmonary Infections in Cystic Fibrosis