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1.1 Schizophrenia Schizophrenia (SZ) typically manifests itself in early adulthood with psychotic symptoms (hallucinations, delusions, disorders of thought or speech, grossly disorganized behaviour), cognitive impairments and in some, negative symptoms. This illness affects 1% of the population worldwide (APA, 1994). Risk factors for schizophrenia suggest both a developmental and genetic basis. Neuropathology and abnormalities in multiple neurotransmitter systems have been reported throughout the brain (Harrison 1999; Powers 1999). However, there is no diagnostic pathology that identifies the brains of SZ subjects.

Ultrastructural Distinctions Between Treatment Responders and Non-Responders in Schizophrenia: Postmortem Studies of the Striatum