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Overt thyroid disease often involves mood disorders and cognitive impairment in adults. But at the subclinical level a relationship has been difficult to establish. Some authors regard thyroid stimulant hormone small elevation in the elderly as part of aging. However, there is a body of studies that demonstrate the impact of SH in target tissues; vg, ejection fraction and lipid profile alterations; thus many experts recommend comprehensive treatment, adjusting it to the patient s specific context, age, comorbidities etc. However, regarding cognitive and mood problems there is still controversy. There are studies concluding no association between SH, cognition or depression but these used insensitive instruments to measure cognition and depression, or they had some other methodological bias. There are also cross-sectional and case studies showing an association with newlydeveloped more sensitive instruments. Subclinical hypothyroidism, cognitive impairment and depression occur more often in old age. Population aging increases SH, cognitive impairment, and depression prevalence and this will be a health burthen for patients, their families, and society; thus measures to minimize it is urgent in developing countries, where a high increase in the elderly population is expected. Indeed Heathcare polices everywhere must strive for mind and physical well-being. We will review instruments to screen and score different spheres of cognitive function in the geriatric or general practitioner s office, and assess the available evidence, and aspects that need further investigation.

Cognitive Function in Elderly with Subclinical Hypothyroidism