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Olive oil is a natural product of Olea europaea. It contains triacylglycerols of unsaturated and saturated fatty acids as well as free acids and numerous other biologically active components. Modern pharmaceutical industries are turning to natural herbal sources in order to find effective, low allergenic and non-irritating components that can be used in drug delivery systems or as recipients for both hydrophobic and hydrophilic active agents. Combining hydrophobic compounds with olive oil components is not problematic at all. However, this is quite different for hydrophilic compounds. One possible way for overcoming this problem is by mechanochemical treatment. This method has become widespread for preparing powdered solid materials in a large variety of compositions and involves the use of a conventional high-energy ball mill to initiate chemical reactions and structural changes of materials in solid-phase processes. Mechanochemical activation appears to be an environmentally friendly method, since it does not require organic solvents (Grigorieva et al., 2004; Margetic, 2005; Lugovskoy et al., 2008; Lugovskoy et al., 2009). It was shown that the mechanochemical method enabled some olive oil components to covalently attach to talc or to titanium dioxide the solid ingredients of creams, ointments and powders (Nisnevitch et al., 2011). The remaining components were deeply absorbed by solid phases. New solid-phase composite materials which combined useful properties of various components with a different nature were thus created. Talc combined with olive oil exhibited good antioxidant properties scavenging ca. 40% of free radicals. Olive oil phenols with one or two hydroxyl groups, such as hydroxytyrosol, caffeic acid, photocatechuic acid, syringic acid, derivatives of elenolic acid, derivatives of oleuropein, tyrosol and some others are among the olive oil components responsible for its in vitro antioxidative activity (Papadopoulos & Boskou 1991; Briante et al., 2001; Lesage-Meessen et al., 2001; Tovar et al., 2001; Vissers et al., 2004). These compounds retain their antioxidant properties when combined with talc by a mechanochemical method. Furthermore, the possibility of combining water-soluble ascorbic acid (vitamin C) with olive oil on a talc or titanium dioxide support using mechanochemical activation has been reported (Nisnevitch et al., 2011). These triple mixtures (support-olive oil-ascorbic acid) scavenged free radicals instantly and totally due to the presence of ascorbic acid, which is a well-known effective

Olive Oil-Based Delivery of Photosensitizers for Bacterial Eradication