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The mitogen-activated protein kinase (MAPK) signal transduction pathway is required to promote skeletal myogenesis and maintain skeletal muscle function. Although it has been long appreciated that the MAPK pathway plays a critical role in skeletal myogenesis it is still unclear as to whether the MAPKs are involved in the development of skeletal muscle diseases such as muscular dystrophies. Much evidence has demonstrated that MAPK activation is important for skeletal myogenesis. The cessation of MAPK activity is also an important part of the process of skeletal myogenesis. The MAPK phosphatases (MKPs) are responsible for inactivating the MAPKs. The role of the MKPs in physiological and pathophysiological functions of skeletal muscle remains to be fully understood. In this review, we will summarize the current state of understanding of the functional roles of the MAPKs, and the emerging role of the MKPs in the regulation of physiological skeletal muscle function, and their potential involvement in skeletal muscle diseases.

Mitogen-Activated Protein Kinases and Mitogen-Activated Protein Kinase Phosphatases in Regenerative Myogenesis and Muscular Dystrophy