English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor disease with a still dismal prognosis for the patients. Since the tumor is mostly detected only in an advanced stage when the tumor has already metastasized, therapeutic options are quite limited. Moreover, this tumor is characterized by a profound resistance towards cytostatic drugs essentially hampering chemotherapy and reducing survival times of PDAC patients. The expression of the adhesion molecule L1CAM (CD171) has been recently reported to be associated with a chemoresistant and migratory phenotype of PDAC cells. L1CAM is a member of the immunoglobulin superfamily and has been initially found to play a role during the development of the nervous system. Meanwhile, L1CAM has been detected in numerous cancer tissues including PDAC and its elevated expression correlates with poor prognosis for the patients. Moreover, L1CAM has been shown to play an important role in different cellular processes involved in tumorigenesis such as cell migration and invasion, proliferation, survival and chemoresistance. Accordingly, inhibition of L1CAM by means of RNA interference or antibody-mediated blockade markedly reduced migration and proliferation of tumor cells and increased their chemosensitivity. Several preclinical studies e.g. in mouse model sytems for PDAC already demonstrated considerable anti-tumor effects with significantly reduced tumor outgrowth and tumor cell dissemination along with prolonged survival. Altogether, these data point to the suitability of L1CAM as a therapeutic target for an improved therapy of PDAC.

The Adhesion Molecule L1CAM as a Novel Therapeutic Target for Treatment of Pancreatic Cancer Patients?