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The concentration of steroid hormones in arteries varies according to the site of blood sampling. The hormone concentration is higher in the ovarian and testicular arteries than in the aorta resulting in a high impact on the target organs, opening a route for local hormonal regulation between organs. Local application of drugs may induce a potential method for semi-specific treatments. Vaginal application of hormones will therefore induce relatively higher concentrations in the uterus and urinary bladder area than a peripheral application. Likewise, nasal application will induce a higher relative concentration in brain arterial blood than peripheral application. This is due to local counter-current transfer between venous and arterial blood, and between the lymphatic and arterial vessels. Similarly, the concentration of steroids in peritoneal fluid varies according to the site of sampling.

The Concentration of Steroid Hormones in Blood and Peritoneal Fluid Depends on the Site of Sampling