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Crohn’s Disease (CD), together with ulcerative colitis (UC) belongs to inflammatory bowel diseases (IBD). Among its typical symptoms are inflammation, abdominal pain, melaena, diarrhea, ulcers and even fistulas. So far the etiology of CD remains unclear, but what is certain, is that it is multifactorial. Causing chronic inflammation and starting an immunological response requires both genetic factors, as well as environmental ones. What is more, CD is multigenetic – various genes could be a potential cause of the disease; among them are e.g. CARD15/NOD2, ATG16L1 and IL23R (Barrett et al., 2008; Cukovic-Cavka 2006, Cho 2008, Lesage 2002).

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Genotyping of CARD15/NOD2, ATG16L1 and IL23R Genes in Polish Crohn’s Disease (CD) Patients – Are They Related to the Localization of the Disease and Extra-Intestinal Symptoms?