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QMRA, quantitative magnetic resonance angiography, is currently the only non-invasive modality with which to quantify blood flow in the human vasculature. Dr. Fady Charbel, a vascular neurosurgeon at the University of Chicago, spearheaded the application of this technology to the cerebrovascular system. Knowledge and experience garnered through years of research by Dr. Charbel and others on computer modeling and circulatory fluid dynamics culminated in the development of computer software referred to as non-invasive optimal vessel analysis (NOVA) (Zhao et al., 2000). QMRA uses traditional time-of-flight and phase-contrast MRI to visualize extracranial and intracranial vascular anatomy and measure volumetric blood flow. VasSol Inc., through which the software is now commercially available, acquired pre-market FDA approval for the technology in 2002.

Clinical Applications of Quantitative MRA in Neurovascular Practice