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Current statistics from the World Health Organization, Heart and Stroke Foundation of Canada, and the American Heart Association show that cardiovascular disease remains a leading cause of death (Heart and Stroke Foundation of Canada [HSFO], 2011; Roger et al., 2011; World Health Organization [WHO], 2011). Innovative and integrative approaches aimed at understanding and treating heart disease are needed. In this chapter we introduce a novel field of investigation called cardiovascular circadian proteomics. This approach is based on the application of high throughput proteomic technologies for discovery of molecular processes in cardiovascular tissues over the 24-hour day/night cycles. Time is a crucial but frequently overlooked factor affecting our physiology in health and disease. Circadian cardiovascular proteomics offers considerable promise to advance our understanding of heart disease (indeed disease in general), and opens new avenues for treatment of patients clinically.

Circadian Proteomics and Its Unique Advantage for Discovery of Biomarkers of Heart Disease